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TIMI Score Calculator for UA/NSTEMI

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Calculate the TIMI Risk Score for unstable angina and NSTEMI from seven clinical criteria, with published 14-day risk of death, MI, or urgent revascularization.

Reviewed by the thecalcu.com team · Last updated July 5, 2026

Age ≥ 65 Years (1 pt)

≥3 Risk Factors for CAD (Family History, Hypertension, Hypercholesterolemia, Diabetes, Current Smoker) (1 pt)

Known CAD (Stenosis ≥50%) (1 pt)

Aspirin Use in Prior 7 Days (1 pt)

Severe Angina (≥2 Episodes in Preceding 24 Hours) (1 pt)

ST-Segment Deviation ≥0.5 mm (1 pt)

Elevated Cardiac Biomarkers (1 pt)

TIMI UA/NSTEMI Score

0/ 7

14-Day Risk of Death/MI/Urgent Revascularization

—

Not a substitute for clinical judgment. ACS management and triage decisions must be made by a qualified healthcare provider — this score is one input among many, never the sole basis for care.

What is a TIMI UA/NSTEMI?

The TIMI Score Calculator for UA/NSTEMI computes the TIMI Risk Score for unstable angina and non-ST-elevation myocardial infarction, a validated tool that estimates the 14-day risk of death, MI, or urgent revascularization based on seven equally weighted clinical criteria.

Select the applicable criteria to see your total score and the corresponding published 14-day risk. For related acute coronary syndrome risk tools, see the GRACE Calculator, HEART Score Calculator, and TIMI Score for STEMI Calculator.

Why Use a TIMI UA/NSTEMI Score Calculator?

Manually tallying seven criteria and mapping the resulting sum to the correct published risk percentage is easy to get wrong under time pressure. This calculator handles both steps instantly and shows exactly which factors are contributing to the total.

It's a useful quick reference for reviewing how each individual factor contributes to the overall estimated 14-day risk following unstable angina or NSTEMI.

Who Should Use This Calculator?

Emergency medicine and cardiology trainees learning acute coronary syndrome risk stratification can use this tool to check worked TIMI UA/NSTEMI examples against the original published criteria and risk table. Patients or family members trying to understand a physician's explanation of near-term cardiac risk may use it as an educational reference.

This calculator is strictly for informational and educational purposes and is not a substitute for a physician's clinical judgment. Unstable angina and NSTEMI require urgent evaluation and management, and all diagnostic and treatment decisions must be made by a qualified healthcare provider, this tool must never be used to delay care or to make real-time clinical decisions.

What Insights Does the TIMI UA/NSTEMI Score Calculator Give You?

TIMI UA/NSTEMI Score is the primary result, your total points out of a possible 7, based on the criteria you selected.

14-Day Risk of Death/MI/Urgent Revascularization shows the published percentage risk associated with your total score, from the original Antman et al. 2000 derivation and validation cohorts.

How to use this TIMI UA/NSTEMI calculator

  1. Select Yes or No for Age ≥ 65 Years.
  2. Select Yes or No for ≥3 Risk Factors for CAD.
  3. Select Yes or No for Known CAD (Stenosis ≥50%).
  4. Select Yes or No for Aspirin Use in Prior 7 Days.
  5. Select Yes or No for Severe Angina (≥2 Episodes in Preceding 24 Hours).
  6. Select Yes or No for ST-Segment Deviation ≥0.5 mm.
  7. Select Yes or No for Elevated Cardiac Biomarkers.
  8. Review your TIMI Score and 14-Day Risk, and discuss the result with your care team.
Show formula & methodology ↓Show less ↑

Formula & Methodology

The TIMI UA/NSTEMI score sums the following points, each worth 1 point if present:

- Age ≥65 years: 1 point
- ≥3 risk factors for CAD: 1 point
- Known CAD (stenosis ≥50%): 1 point
- Aspirin use in prior 7 days: 1 point
- Severe angina (≥2 episodes in 24 hours): 1 point
- ST-segment deviation ≥0.5 mm: 1 point
- Elevated cardiac biomarkers: 1 point

Published 14-day risk by score (Antman EM, et al. JAMA. 2000;284:835-842): 0-1 → 4.7%, 2 → 8.3%, 3 → 13.2%, 4 → 19.9%, 5 → 26.2%, 6-7 → 40.9%.

Worked example: A patient aged 68 (1 point) with known CAD (1 point), aspirin use in the prior week (1 point), and elevated cardiac biomarkers (1 point) scores 1 + 1 + 1 + 1 = 4 points total, corresponding to an estimated 14-day risk of approximately 19.9%.

Frequently Asked Questions

What is the TIMI Risk Score for UA/NSTEMI?
The TIMI Risk Score for unstable angina and non-ST-elevation myocardial infarction (UA/NSTEMI) is a validated clinical tool that estimates the 14-day risk of death, myocardial infarction, or urgent revascularization, based on seven equally weighted clinical criteria. It was developed by Antman EM, et al. and published in JAMA in 2000.
What are the seven TIMI UA/NSTEMI criteria?
The criteria are: age 65 or older, three or more risk factors for coronary artery disease, known coronary artery disease (stenosis ≥50%), aspirin use in the prior 7 days, severe angina (2 or more episodes in 24 hours), ST-segment deviation of 0.5 mm or more, and elevated cardiac biomarkers. Each present criterion adds 1 point, for a maximum of 7.
What does the resulting risk percentage represent?
It represents the estimated 14-day risk of the composite endpoint of death, new or recurrent myocardial infarction, or severe recurrent ischemia requiring urgent revascularization, based on the original derivation and validation cohorts from the TIMI 11B and ESSENCE trials.
Why does prior aspirin use count as a risk factor?
Aspirin use in the prior 7 days was found to be an independent predictor of adverse outcomes in the derivation cohort, possibly reflecting that patients already on aspirin who still develop acute coronary syndrome represent a higher-risk population, such as those with more advanced or resistant atherosclerotic disease.
What counts as 'elevated cardiac biomarkers'?
This refers to elevated cardiac-specific biomarkers such as troponin or CK-MB above the locally defined upper reference limit, indicating myocardial injury, and is typically determined by laboratory testing rather than clinical assessment alone.
Can the TIMI UA/NSTEMI score guide treatment intensity?
The score is often used to help identify higher-risk patients who may benefit from a more intensive early invasive strategy, but the specific treatment approach for any individual patient is always determined by the treating cardiology team based on the complete clinical picture, not by the score alone.
How is this different from the TIMI STEMI score?
This score uses seven equally weighted binary criteria and estimates 14-day risk of death, MI, or urgent revascularization for UA/NSTEMI patients, while the TIMI Score for STEMI Calculator uses differently weighted factors and estimates 30-day mortality specifically after ST-elevation MI, they apply to different presentations and endpoints.
Does a score of 0-1 mean no cardiac risk at all?
A score of 0-1 corresponds to the lowest risk category in the original validation data (around 4.7%), but this still represents a real, non-zero risk of the composite endpoint, and ongoing clinical monitoring remains essential regardless of score.
How does risk factor count for CAD get determined?
The 'three or more risk factors for CAD' criterion counts family history of coronary disease, hypertension, hypercholesterolemia, diabetes, and current smoking status, a patient needs at least three of these five factors present to satisfy this specific criterion.
Is the TIMI UA/NSTEMI score still used alongside newer tools like GRACE?
Yes, both the TIMI and GRACE scores remain in active clinical use, often for different purposes; TIMI is valued for its simplicity, while the GRACE Calculator offers a more granular risk estimate validated across the full spectrum of acute coronary syndromes.
Can this calculator replace emergency evaluation for chest pain?
No, this calculator is strictly for informational and educational purposes only. Chest pain and suspected acute coronary syndrome require urgent evaluation by a qualified healthcare provider, and this tool must never be used to delay care or as a substitute for real-time clinical decision-making.
Who typically uses this score in clinical practice?
Emergency physicians and cardiologists use it primarily for risk stratification and to help guide the intensity and timing of further evaluation in patients with unstable angina or NSTEMI, while trainees use it to study the relationship between clinical risk factors and short-term cardiac outcomes.
Also known as
TIMI risk score UA calculatorNSTEMI risk score calculatorAntman TIMI score calculatorunstable angina risk calculatorTIMI 14-day risk calculator